Salisbury, UK, 9th March 2013: NanoSight reports on the new NS300 system based on their world-leading Nanoparticle Tracking Analysis technology.

The NS300 utilizes the latest version of NanoSight‘s particle characterization technology, Nanoparticle Tracking Analysis (NTA). This elegant new instrument offers the unique benefits scientists have come to expect from NanoSight in a compact format, with a major benefit of enhanced fluorescence capability.

The NS300 can visualize and measure particles in suspension in the size range of 10-1000 nm (material dependent), and addresses the needs of a wide variety of applications including protein aggregation, exosome and microvesicle research, and drug delivery systems. It contributes to characterization under the new EU Definition of Nanomaterials, and is particularly suited to the analysis of particles labeled with fluorescent quantum dots.

The NS300 instrument provides simultaneous analysis through several filters to give multi-wavelength detection of different fluorophores excited by a single laser.

Dr Patrick Hole, NanoSight‘s head of product development, says of the new instrument "The NS300 is the natural progression from the NS500 and LM10. It takes the most popular features of these instruments and combines them into an easy to use, compact format. We then added in the high capacity motorized fluorescence disc. This disc, capable of being programmed from within the software to present up to six different fluorescent filters, will facilitate a more detailed assessment of fluorophores. It will give users the possibility to analyze each fluorescence population in terms of size and concentration; this ability to identify co-localized fluorophores will greatly enhance specificity and the ability to Phenotype".

Additionally, the software‘s new rheology feature can measure viscosity in the range 0-5 centipoise, using probe particles to inform on non-Newtonian liquids in a shear-free manner, so being specifically applicable to the formation processes of hydrogels.

With a footprint measuring just 40 cm by 25 cm, the NS300 comes complete with a high sensitivity sCMOS camera, temperature control and a choice of laser wavelength. The sample chamber and laser block are designed to be readily removed, to enable easy cleaning and high throughput. The NS300 complements the NanoSight family of instruments by providing an answer to researchers whose laboratory space is at a premium, without compromising on quality or functionality.

Attachment

The new NS300 nanoparticle characterization system from NanoSight

For a high resolution copy of the image, either right click to download or contact Jezz Leckenby at Talking Science.

About NanoSight:
NanoSight delivers the world‘s most versatile and proven multi-parameter nanoparticle analysis in a single instrument.

NanoSight‘s "Nanoparticle Tracking Analysis" (NTA) detects and visualizes populations of nanoparticles in liquids down to 10 nm, dependent on material, and measures the size of each particle from direct observations of diffusion. Additionally, NanoSight measures concentration and a fluorescence mode differentiates suitably-labelled particles within complex background suspensions. Zeta potential measurements are similarly particle-specific. It is this particle-by-particle methodology that takes NTA beyond traditional light scattering and other ensemble techniques in providing high-resolution particle size distributions and validates data with information-rich video files of the particles moving under Brownian motion.

This simultaneous multiparameter characterization matches the demands of complex biological systems, hence its wide application in development of drug delivery systems, of viral vaccines, and in nanotoxicology. This real-time data gives insight into the kinetics of protein aggregation and other time-dependent phenomena in a qualitative and quantitative manner. NanoSight has a growing role in biodiagnostics, being proven in detection and speciation of nanovesicles (exosomes) and microvesicles.

NanoSight has installed more than 500 systems worldwide with users including BASF, GlaxoSmithKline, Merck, Novartis, Pfizer, Proctor and Gamble, Roche and Unilever together with the most eminent universities and research institutes. NanoSight‘s technology is validated by 600+ third party papers citing NanoSight results. NanoSight‘s leadership position in nanoparticle characterization is consolidated further with publication of an ASTM International standard, ASTM E2834, which describes the NTA methodology for detection and analysis of nanoparticles. For more information, visit www.nanosight.com.

For further information:
Please contact NanoSight direct or their marketing agency, Talking Science:
NanoSight Limited
Minton Park
London Road
Amesbury SP4 7RT UK
T +44(0)1980 676060
F +44(0)1980 624703
www.nanosight.com
sarah.newell@nanosight.com

Talking Science Limited
39 de Bohun Court
Saffron Walden
Essex CB10 2BA UK
T +44(0)1799 521881
M +44(0)7843 012997
www.talking-science.com
jezz@talking-science.com